Two female patients with Cushing´s syndrome were ´´reported. The diagnosis was confirmed by clinical features,. biochemical;, hormonal, radiological studi- and final pathologic examinations after surgery. On; ´pathologic examination, the one case was ctanioph ryngio ma., invading the pituitary gland and the oth. case was right adrenocortical adenoma. After ope - tion both cases were improved significantly in clinic. I and laboratory findings.
In the case of craniopharyngioma, the ba .1 excretion. . of urinary 17-OHCS and 17-KS were dro,ped significantly compared with preoperative value after sur-gery." Urinary 17-OHCS and 17-KS value- persisted. within upper limit of normal range and p tuitary-adrenal axis was recovered, but the diurnal v: nation of the plasma cortisol did not return to nor em al until 4 - months after surgery. So, it might be ex i ected that Cushing´s disease with grossly visible hypot a alamic or pituitary tumor, when present as the prim ry etiologic factor in pituitary dependent Cushing´s syndrome, might be cured by resection of the tumo and initial therapy is best directed at the pituita y or hypothalamic tumor. The case of Cushing´s syndrome associated with craniopharyngioma seems o be `not reported and its mechanism of Cushing´s syndrome due to craniopharyngioma is also not clear.
We have reviewed literatures of Cushing s syndrome and discussed our cases.
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